𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Solid phase synthesis of oligonucleotides containing 3′-thiothymidine

✍ Scribed by Richard Cosstick; Joseph S. Vyle

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
254 KB
Volume
30
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Summarv-A 5'-O-monomethoxytritylthymidine-3'-S-thiophosphoramidite (3) has been used to prepare oligodeoxynucleotides containing 3'-thiothymidine on a solid phase support. The intermediate thiophosphites are most efficiently oxidised using tetrabutylammonium periodate. Polynucleotide analogues containing modified internucleotide linkages are receiving considerable attention as potential therapeutic agents1 and tools for the manipulation of DNA2. The phosphorothioate2r3 and phosphorodithioare*

📜 SIMILAR VOLUMES

Automated solid-phase synthesis of branc
Automated solid-phase synthesis of branched oligonucleotides
✍ Masad J. Damha; Steve Zabarylo 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 205 KB

A general procedure for the synthesis of branched RNA and DNA oligonucleotides has been developed. The synthetic strategy involves the 3'->5' synthesis of a DNA or RNA oligomer on a solid-phase, controlled-pore glass support with an automated DNA synthesizer. The branch point nucleoside is introduce

The synthesis of oligodeoxynucleotides c
The synthesis of oligodeoxynucleotides containing 4-thiothymidine residues
✍ Theo T. Nikiforov; Bernard A. Cornolly 📂 Article 📅 1991 🏛 Elsevier Science 🌐 French ⚖ 282 KB

Olgodeoqnucleotides contarnug 4-thothymzdm residues were obtauwdusing the ph~?sphoramtdttes of 2 and J Treatment with CHJOSK tn EtOH was used to rntroduce the I-throketo $mctron at the olqodeoqnucleotrde level. Recently, we have reported the synthesis of 5'-0-(4,4'-dimethoxytrity1)-4-throcyanatothy