Solid phase synthesis of neutral oligonucleotide analogues
โ Scribed by Haiyan Wang; Dwight D. Weller
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 161 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
A general procedure for the synthesis of branched RNA and DNA oligonucleotides has been developed. The synthetic strategy involves the 3'->5' synthesis of a DNA or RNA oligomer on a solid-phase, controlled-pore glass support with an automated DNA synthesizer. The branch point nucleoside is introduce
Summarv-A 5'-O-monomethoxytritylthymidine-3'-S-thiophosphoramidite (3) has been used to prepare oligodeoxynucleotides containing 3'-thiothymidine on a solid phase support. The intermediate thiophosphites are most efficiently oxidised using tetrabutylammonium periodate. Polynucleotide analogues conta
Syntheses of cyclosporine analogues are reported wherein the peptide couplings were achieved in solid phase. The Wang resin was used as the solid support, and the peptide couplings commenced with the residue 11 of the cyclosporine skeleton. The couplings proceeded in a stepwide manner up to the res