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Solid-Phase Synthesis of Isoxazole-Based Amino Acids: A New Scaffold for Molecular Diversity

✍ Scribed by De Luca, Lidia; Giacomelli, Giampaolo; Riu, Antonella


Book ID
115514715
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
55 KB
Volume
66
Category
Article
ISSN
0022-3263

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N-Fmoc-dehydroalanine: a versatile molec
✍ Brendan A Burkett; Christina L.L Chai πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 141 KB

The synthesis of polymer-supported N-Fmoc-dehydroalanine starting from S-protected cysteine via an oxidation/elimination strategy is described. Cycloaddition with a range of dienes aorded a range of conformationally constrained amino acids in moderate yields. The potential applications of this metho