A Constrained Diketopiperazine as a New
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Jean-François Pons; Jean-Luc Fauchère; Frédéric Lamaty; Annie Molla; René Lazaro
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Article
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1998
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John Wiley and Sons
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English
β 523 KB
As a new scaffold for peptidomimetic synthesis, a highly constrained bifunctional diketopiperazine, 4, has been prepared by smooth N-alkylation with tert-butyl bromoacetate. As a first application, we describe herein the synthesis of new