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A Constrained Diketopiperazine as a New Scaffold for the Synthesis of Peptidomimetics

✍ Scribed by Jean-François Pons; Jean-Luc Fauchère; Frédéric Lamaty; Annie Molla; René Lazaro

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
523 KB
Volume
1998
Category
Article
ISSN
1434-193X

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✦ Synopsis

As a new scaffold for peptidomimetic synthesis, a highly constrained bifunctional diketopiperazine, 4, has been prepared by smooth N-alkylation with tert-butyl bromoacetate. As a first application, we describe herein the synthesis of new

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