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ChemInform Abstract: Synthesis of New Perhydro-(1,4)-diazepin-2-ones as Constrained Peptidomimetics.

โœ Scribed by A. NOUVET; F. LAMATY; R. LAZARO

Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
29
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Stereoselective Syn
ChemInform Abstract: Stereoselective Synthesis of 1,3-Disubstituted Hexahydro-1,4-diazepin- 2-ones.
โœ A. POHLMANN; D. GUILLAUME; J.-C. QUIRION; H.-P. HUSSON ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 29 KB ๐Ÿ‘ 1 views

Stereoselective Synthesis of 1,3-Disubstituted Hexahydro-1,4diazepin-2-ones. -A fast and facile asymmetric synthesis of the title compounds (VI), a kind of constrained peptides, involving the diastereoselective alkylation of optically pure hydroxylactam (IV) as the key step is described.