Solid phase synthesis of peptide hydroxa
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Jack J. Chen; Arno F. Spatola
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Article
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1997
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Elsevier Science
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French
β 225 KB
The synthesis of peptide hydroxamic acids has been performed on a solid support. A carboxyl group of a peptide synthesized on/xTa-methylbenzhydrylaminΒ’ (pMBHA) resin was converted to a hydroxamate functional group by condensing with NH2OBzl, which was found preferable to NH2OtBu or NH2OTrt. The hydr