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Solid phase synthesis of hydroxamate peptides for histone deacetylase inhibition

✍ Scribed by Wilson, David M.; Silverman, Lisa N.; Bergauer, Markus; Keshari, Kayvan R.


Book ID
118049460
Publisher
Elsevier Science
Year
2013
Tongue
French
Weight
472 KB
Volume
54
Category
Article
ISSN
0040-4039

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Solid phase synthesis of peptide hydroxa
✍ Jack J. Chen; Arno F. Spatola πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 225 KB

The synthesis of peptide hydroxamic acids has been performed on a solid support. A carboxyl group of a peptide synthesized on/xTa-methylbenzhydrylaminΒ’ (pMBHA) resin was converted to a hydroxamate functional group by condensing with NH2OBzl, which was found preferable to NH2OtBu or NH2OTrt. The hydr