The synthesis of peptide hydroxamic acids has been performed on a solid support. A carboxyl group of a peptide synthesized on/xTa-methylbenzhydrylaminΒ’ (pMBHA) resin was converted to a hydroxamate functional group by condensing with NH2OBzl, which was found preferable to NH2OtBu or NH2OTrt. The hydr
Solid-Phase Synthesis of C-Terminal Peptide Hydroxamic Acids
β Scribed by Zhang, Wei; Zhang, Lianshan; Li, Xianfeng; Weigel, John A.; Hall, Steven E.; Mayer, John P.
- Book ID
- 127049271
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 26 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1520-4766
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract In this paper, a straightforward and generic protocol is presented to label the __C__βterminus of a peptide with any desired moiety that is functionalized with a primary amine. Amineβfunctional molecules included are polymers (useful for hybrid polymers), long alkyl chains (used in pept
## Abstract Solidβphase synthesis of biomolecules, of which peptides are the principal example, is well established. However, synthetic peptides containing modifications at the carboxy termini are often desired because of their potential therapeutic properties. As a result, there is a necessity for