Solid-Phase Synthesis of a Library of Hydroxyproline Derivatives
โ Scribed by Vergnon, Anne L.; Pottorf, Richard S.; Player, Mark R.
- Book ID
- 118235232
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 137 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1520-4766
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Cyclic peptides are excellent tools to investigate the functional and spatial requirements for ligands to bind to a given target. In this paper we report the synthesis of a library of cyclic hexapeptides, designed to be Selectin antagonists. Based on molecular modelling calculations, these peptides
An efficient protocol for the preparation of combinatorial libraries is described. The methodology first deploys solid phase chemistry to synthesize a 96-well array of intermediates linked to resin via a latent reactive functionality such as a benzyl ether, tert-amine or thioether. Cleavage from the