✦ LIBER ✦

Library synthesis using solution phase capping of solid phase derived intermediates

✍ Scribed by Simon J Teague; Iain A.S Walters

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 78 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)00094-0

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✦ Synopsis

An efficient protocol for the preparation of combinatorial libraries is described. The methodology first deploys solid phase chemistry to synthesize a 96-well array of intermediates linked to resin via a latent reactive functionality such as a benzyl ether, tert-amine or thioether. Cleavage from the resin is accompanied by transformation of the linker to a reactive functionality, namely a benzyl halide, sec-amine or thiol. Aliquots of this array of reactive intermediates are each capped with a different solution phase reactant to deliver the final library in 96-well format, ready for high throughput screening.

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