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Combination of solid phase and solution phase synthesis of oligosaccharides using sonication

✍ Scribed by Christabel T. Tanifum; Jianjun Zhang; Cheng-Wei T. Chang

Publisher: Elsevier Science
Year: 2010
Tongue: French
Weight: 642 KB
Volume: 51
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.06.027

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✦ Synopsis

An approach that combines solid phase and solution phase synthesis of oligosaccharides via the assistance of sonication has been developed. By employing the traceless linker, the designed oligosaccharides can be obtained in pure form and, more importantly, ready for incorporation to aglycons of interest via 'Click' chemistry or amide linkage. The overall strategy will facilitate the studies of roles of carbohydrates in bioactive compounds.

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