Solid phase synthesis of polylactosamine oligosaccharide

✍ Scribed by Hiroki Shimizu; Yukishige Ito; Osamu Kanie; Tomoya Ogawa

• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 291 KB
• Volume: 6
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(96)00535-5

✦ Synopsis

Solid phase synthesis of polylactosamine oligosaccharide was performed starting from resin supported lactose la,b. Glycosylation of la with the lactosamine unit 6 followed by delevulinoylation afforded tetrasaccharides, which were further converted into hexa-and octasaccharide and was cleaved from resin by TrBF4 in CH2CI2 to afford 7. Ester linked lb was converted in a similar manner into hexasaccharide that was liberated under basic conditions to give 8. Subsequent deprotection into 9 was performed in three steps.