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Solid phase synthesis of 1-aminohydantoin libraries

✍ Scribed by Lawrence J. Wilson; Min Li; David E. Portlock

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
266 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

The solid support synthesis of a series of l-aminohydantoins based on a diverse set of hydrazino amino acids, aldehydes, and amines is described. The method involves the construction of resin attached hydrazino acid precursors, followed by subsequent derivatization, and then cyclizative cleavage off the resin. Overall yields vary per example between 15and60%, and the samples are suitable for biological evaluations without further purification.

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