A Solid Phase Library Synthesis of Hydroxyindoline-Derived Tricyclic Derivatives by Mitsunobu Approach
โ Scribed by Arya, Prabhat; Wei, Chang-Qing; Barnes, Michael L.; Daroszewska, Malgosia
- Book ID
- 125521836
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 175 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1520-4766
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
An efficient protocol for the preparation of combinatorial libraries is described. The methodology first deploys solid phase chemistry to synthesize a 96-well array of intermediates linked to resin via a latent reactive functionality such as a benzyl ether, tert-amine or thioether. Cleavage from the
The 16p-(azidopropyl) derivative of estradiol ( 7) was synthesized and coupled to aminomethyl resin via a photolabile o-nitrobenzyl linker. Condensation of the corresponding iminophosphorane with activated acids successfully gave amides. Photocleavage resulted in good yield recovery of estradiol der