Solid-Phase Synthesis of 1,7-Disubstituted-1,3,5-triazepane-2,4-diones
β Scribed by Yu, Yongping; Ostresh, John M.; Houghten, Richard A.
- Book ID
- 127250050
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 44 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1523-7060
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The solid phase synthesis of 1,3,4,7-Tetrasubstituted Perhydro-l,4-diazepine-2,5-diones is described. Starting from the resin-bound tBu ester ofaspartic acid and employing reductive alkylation and
A traceless synthesis of 1,2,4-triazolidine-3,5-diones has been achieved through cyclo-elimination from solid-phase. This traceless cyclo-elimination release step is induced by catalytic amount of base or by simply refluxing the urea carbamate intermediate.
We report here the synthesis of 3,7-disubstituted perhydro-1,4-diazepine-2,5-diones from amino acids and b-amino acids using a backbone amide linker (BAL) as a cis-configuration inductor. We have optimized each steps of the synthesis on solid support using Mimotopes crowns.