Solid phase synthesis of 1,4-benzodiazepine-2,5-diones
โ Scribed by John P. Mayer; Jingwen Zhang; Kirsten Bjergarde; Doug M. Lenz; John J. Gaudino
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 171 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract An efficient solidโphase synthetic method for 2,3,4,5โTetrahydroโ1,4โbenzodiazepinโ2,5โdiones, having amine derivatives on the benzene ring, was developed. This method has been successfully applied to the synthesis of several spatially separated drugโlike and informationโrich smallโmole
## Abstract For Abstract see ChemInform Abstract in Full Text.
The solid phase synthesis of 1,3,4,7-Tetrasubstituted Perhydro-l,4-diazepine-2,5-diones is described. Starting from the resin-bound tBu ester ofaspartic acid and employing reductive alkylation and
A traceless synthesis of 1,2,4-triazolidine-3,5-diones has been achieved through cyclo-elimination from solid-phase. This traceless cyclo-elimination release step is induced by catalytic amount of base or by simply refluxing the urea carbamate intermediate.