𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Solid phase synthesis of 1,3,4,7-Tetrasubstituted Perhydro-1,4-diazepine-2,5-diones

✍ Scribed by Adel Nefzi; John M Ostresh; Richard A Houghten

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
168 KB
Volume
38
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

The solid phase synthesis of 1,3,4,7-Tetrasubstituted Perhydro-l,4-diazepine-2,5-diones is described. Starting from the resin-bound tBu ester ofaspartic acid and employing reductive alkylation and

📜 SIMILAR VOLUMES

Solid-phase synthesis of 3,7-disubstitut
Solid-phase synthesis of 3,7-disubstituted perhydro-1,4-diazepine-2,5-diones from amino acids and β-amino acids
✍ Jérôme Giovannoni; Gilles Subra; Muriel Amblard; Jean Martinez 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 71 KB

We report here the synthesis of 3,7-disubstituted perhydro-1,4-diazepine-2,5-diones from amino acids and b-amino acids using a backbone amide linker (BAL) as a cis-configuration inductor. We have optimized each steps of the synthesis on solid support using Mimotopes crowns.

Synthesis of new 6-(4-chlorophenyl)perhy
Synthesis of new 6-(4-chlorophenyl)perhydro-1,3-diazepine-2,4-diones via ureidobutyric acids
✍ Jean Guillon; Pascal Sonnet; Patrick Dallemagne; Hugues Miel; Sylvain Rault; Mar 📂 Article 📅 1998 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 371 KB

## Abstract Synthesis of new 6‐(4‐chlorophenyl)perhydro‐1,3‐diazepine‐2,4‐diones was accomplished starting from 4‐amino‐3‐(4‐chlorophenyl)butyric acid (Baclofen). The chemical pathway involved the cyclisation of various 3‐(4‐chlorophenyl)‐4‐ureidobutyric acids. However, none of the new derivatives

Solid-phase synthesis of 1,2,4-triazolid
Solid-phase synthesis of 1,2,4-triazolidine-3,5-diones
✍ Kyung-Ho Park; Linda J Cox 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 56 KB

A traceless synthesis of 1,2,4-triazolidine-3,5-diones has been achieved through cyclo-elimination from solid-phase. This traceless cyclo-elimination release step is induced by catalytic amount of base or by simply refluxing the urea carbamate intermediate.