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Synthesis of new 6-(4-chlorophenyl)perhydro-1,3-diazepine-2,4-diones via ureidobutyric acids

✍ Scribed by Jean Guillon; Pascal Sonnet; Patrick Dallemagne; Hugues Miel; Sylvain Rault; Martine Daoust; Michel Boulouard

Publisher: Journal of Heterocyclic Chemistry
Year: 1998
Tongue: English
Weight: 371 KB
Volume: 35
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570350308

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Synthesis of new 6‐(4‐chlorophenyl)perhydro‐1,3‐diazepine‐2,4‐diones was accomplished starting from 4‐amino‐3‐(4‐chlorophenyl)butyric acid (Baclofen). The chemical pathway involved the cyclisation of various 3‐(4‐chlorophenyl)‐4‐ureidobutyric acids. However, none of the new derivatives retained the anticonvulsant activity of their six‐membered ring homologues, belonging to the phenylpyrimidinedione series which we recently described.

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