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Solid-phase synthesis of 1,2,4-triazolidine-3,5-diones

✍ Scribed by Kyung-Ho Park; Linda J Cox

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 56 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00701-3

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✦ Synopsis

A traceless synthesis of 1,2,4-triazolidine-3,5-diones has been achieved through cyclo-elimination from solid-phase. This traceless cyclo-elimination release step is induced by catalytic amount of base or by simply refluxing the urea carbamate intermediate.

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