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Solid-phase synthesis: a linker for side-chain anchoring of arginine

✍ Scribed by Oscar Garcı́a; Ernesto Nicolás; Fernando Albericio

Book ID
104253877
Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
125 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

A new linker based on a chroman system is described for the side-chain anchoring of Arg and other guanidine-containing molecules. The system is compatible with the Fmoc/tBu solid-phase strategy, because the release of the final product is achieved by treatment with TFA in the presence of scavengers.

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Side-chain anchoring strategy for solid-phase synthesis of peptide acids with C-terminal cysteine
✍ George Barany; Yongxin Han; Balazs Hargittai; Rong-Qiang Liu; Jaya T. Varkey 📂 Article 📅 2003 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 174 KB 👁 2 views

## Abstract Many naturally occurring peptide acids, e.g., somatostatins, conotoxins, and defensins, contain a cysteine residue at the C‐terminus. Furthermore, installation of C‐terminal cysteine onto epitopic peptide sequences as a preliminary to conjugating such structures to carrier proteins is a