A new linker based on a chroman system is described for the side-chain anchoring of Arg and other guanidine-containing molecules. The system is compatible with the Fmoc/tBu solid-phase strategy, because the release of the final product is achieved by treatment with TFA in the presence of scavengers.
✦ LIBER ✦
Solid-Phase Synthesis of Arginine-Containing Peptides and Fluorogenic Substrates Using a Side-Chain Anchoring Approach
✍ Scribed by Hamzé,, Abdallah; Martinez, Jean; Hernandez, Jean-François
- Book ID
- 121465702
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 318 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0022-3263
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