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Solid phase peptide synthesis on JandaJelTM resin

✍ Scribed by Jason A Moss; Tobin J Dickerson; Kim D Janda

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 199 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)02076-7

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✦ Synopsis

A comparative synthesis of the classic difficult sequence ACP(65-74) on 2% crosslinked JandaJel and 1% crosslinked polystyrene-divinylbenzene, (PS-DVB, Merrifield resin) by Boc/benzyl chemistry is presented. The JandaJel batch used was of nearly double the loading of PS-DVB, yet 12.2% less of the des-Val 65 contaminant was observed in the JandaJel synthesis. These results suggest that the increased swelling of the JandaJel resin relative to traditional Merrifield resin afforded a higher yield of the pure peptide by permitting greater solvent-mediated disruption of secondary structure in the resin-bound peptide.

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