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Solid-phase synthesis of peptide thioacids through hydrothiolysis of resin-bound peptide thioesters

✍ Scribed by Xiaohong Zhang; Xiao-Wei Lu; Chuan-Fa Liu

Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
218 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis

We report that solid-phase hydrothiolysis is an efficient method to convert resin-bound peptide thioesters to thioacids in aqueous buffer by using a total PEG-based resin. Also demonstrated is the use of the so-prepared peptide thioacids in chemoselective amide bond formation reactions.

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