Three short peptides were synthesized on Merrifield resin (PS-DVB) and on polystyrene crosslinked with 1,6-hexanediol diacrylate resin (PS-HDODA) to compare their efficiencies in solid-phase peptide synthesis (SPPS). A 2% crosslinked polymeric system having almost equal capacity was used in both cas
Ionic liquid incorporated polystyrene resin for solid-phase peptide synthesis
β Scribed by Hong-Jun Cho; Sang-Myung Lee; Sungwon Jung; Tae-Kyung Lee; Hyo-Jin Yoon; Yoon-Sik Lee
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 343 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4039
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The synthesis of three hydrophobic peptides, which are partial sequences of thioredoxin, on a newly developed, flexible 1,6-hexanediol diacrylate cross-linked polystyrene, in good yield and purity, is described.
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AbstractΓA 1,4-butanediol dimethacrylate cross-linked polystyrene (PSΒ±BDODMA) support was prepared by aqueous suspension polymerization. The C-terminal amino acid incorporation, N a -Fmoc and Boc-deprotection, acylation reactions and the removal of the target peptide from the support were optimized.