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Solid phase synthesis of hydrophobic peptides on 1,6-hexanediol diacrylate cross-linked polystyrene resin

✍ Scribed by Jaya T. Varkey; V.N. Rajasekharan Pillai

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 98 KB
Volume: 5
Category: Article
ISSN: 1075-2617
DOI: 10.1002/(sici)1099-1387(199912)5:12<577::aid-psc227>3.0.co;2-o

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✦ Synopsis

The synthesis of three hydrophobic peptides, which are partial sequences of thioredoxin, on a newly developed, flexible 1,6-hexanediol diacrylate cross-linked polystyrene, in good yield and purity, is described.

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Merrifield resin and 1,6-hexanediol diacrylate-crosslinked polystyrene resin for solid-phase peptide synthesis: A comparative study

✍ Jaya T. Varkey; V. N. Rajasekharan Pillai 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 131 KB 👁 1 views

Three short peptides were synthesized on Merrifield resin (PS-DVB) and on polystyrene crosslinked with 1,6-hexanediol diacrylate resin (PS-HDODA) to compare their efficiencies in solid-phase peptide synthesis (SPPS). A 2% crosslinked polymeric system having almost equal capacity was used in both cas