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Merrifield resin and 1,6-hexanediol diacrylate-crosslinked polystyrene resin for solid-phase peptide synthesis: A comparative study

✍ Scribed by Jaya T. Varkey; V. N. Rajasekharan Pillai

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 131 KB
Volume: 71
Category: Article
ISSN: 0021-8995
DOI: 10.1002/(sici)1097-4628(19990321)71:12<1933::aid-app1>3.0.co;2-c

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✦ Synopsis

Three short peptides were synthesized on Merrifield resin (PS-DVB) and on polystyrene crosslinked with 1,6-hexanediol diacrylate resin (PS-HDODA) to compare their efficiencies in solid-phase peptide synthesis (SPPS). A 2% crosslinked polymeric system having almost equal capacity was used in both cases. The peptides were synthesized using standard solid-phase methodology. In the case of the PS-HDODA resin, all the couplings were completed by the first coupling and the peptides were obtained in Ͼ 90% yield and Ͼ 95% purity. But in the case of the PS-DVB resin, most of the attachments require two to three couplings and the peptides were obtained in about a 65% yield.

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