Two multi-detachable resin supports, each containing orthogonally removable benzyl and photolabile esters were prepared and applied to the synthesis of Leu-enkephalin and angiotensin. These resins, called Pop and Pon, could be cleaved by acid to give the free peptide, by nucleophiles to give protect
Design and synthesis of a multi-detachable benzhydrylamine-resin for solid phase peptide synthesis
β Scribed by James P. Tam; Richard D. DiMarchi; R.B. Merrifield
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- French
- Weight
- 308 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
## Synopsis Attachment of the side-chain carboxyl of the protected aspartic or glutamic acid ester to the resin support has been established for the solid-phase synthesis of the asparagine or glutamine peptide. After further elongation of the a-amino deprotected resin-bound peptide ester with prot
Solid phase peptide synthesis a8 introduced by Merrifield' and modified by others2 is proving to be a valuable addition to the tools of the peptide chemist.
Three short peptides were synthesized on Merrifield resin (PS-DVB) and on polystyrene crosslinked with 1,6-hexanediol diacrylate resin (PS-HDODA) to compare their efficiencies in solid-phase peptide synthesis (SPPS). A 2% crosslinked polymeric system having almost equal capacity was used in both cas
## a-Amidoalkylation Partial hydrolysis Solid-phase peptide synthesis a b s t r a c t MBHA (4-methylbenzhydrylamine) resin has been extensively used as a solid support for the synthesis of peptide amides. Herein, we prepared the core-shell-type MBHA resin by benzotriazole-catalyzed amidoalkylation