✦ LIBER ✦

Multi-detachable resin supports for solid phase fragment synthesis

✍ Scribed by James P. Tam; Foe S. Tjoeng; R.B. Merrifield

Publisher: Elsevier Science
Year: 1979
Tongue: French
Weight: 255 KB
Volume: 20
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)86754-x

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✦ Synopsis

Two multi-detachable resin supports, each containing orthogonally removable benzyl and photolabile esters were prepared and applied to the synthesis of Leu-enkephalin and angiotensin. These resins, called Pop and Pon, could be cleaved by acid to give the free peptide, by nucleophiles to give protected peptides, and by photolysis to give the protected peptide sti esterified to an oxymethylphenylacetic acid handle. Peptides of the latter type were readily attached to an aminomethyl-resin for further peptide elongation.

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