Polymeric supports for solid phase synthesis
β Scribed by Jeff W Labadie
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 596 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1367-5931
No coin nor oath required. For personal study only.
β¦ Synopsis
The nature of the polymer support plays an integral role in solid phase organic synthesis. Combinatorial and highly parallel synthetic strategies have stimulated the development of new polymer support materials with compositions and properties that allow a broader spectrum of organic transformations. Extension of solid phase organic synthesis to encoded microreactors provides an efficient methodology for preparing large numbers of discrete compounds.
π SIMILAR VOLUMES
An amine-derivatized DOTA has been used to modify the surface of a polymeric support for conventional Solid Phase Peptide Synthesis (SPPS) following standard Fmoc chemistry methods. This methodology was used to synthesize a peptide-DOTA conjugate that was demonstrated to be a PARACEST MRI contrast a