Synthesis and application of a PEGA polymeric support for high capacity continuous flow solid-phase peptide synthesis
β Scribed by Manat Renil; Morten Meldal
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 281 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
## a-Amidoalkylation Partial hydrolysis Solid-phase peptide synthesis a b s t r a c t MBHA (4-methylbenzhydrylamine) resin has been extensively used as a solid support for the synthesis of peptide amides. Herein, we prepared the core-shell-type MBHA resin by benzotriazole-catalyzed amidoalkylation
1. In the Merrifield solid phase peptide synthesis (l), the benzyl ester attachment of the first amino acid residue to the chloromethylated polystyrene has customarily been effected by heating the polymer, the protected amino acid, and a tertiary amine in an inert solvent at 80" for 48 hours. Bodan