✦ LIBER ✦
A facile method for the synthesis of benzyl esters using benzyl bromide or iodide and its application to solid phase and conventional peptide synthesis; attempted sterical selection in solid phase synthesis.
✍ Scribed by Manohar A. Tilak
- Publisher
- Elsevier Science
- Year
- 1968
- Tongue
- French
- Weight
- 230 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
- In the Merrifield solid phase peptide synthesis (l), the benzyl ester attachment of the first amino acid residue to the chloromethylated polystyrene has customarily been effected by heating the polymer, the protected amino acid, and a tertiary amine in an inert solvent at 80" for 48 hours.
Bodanszky and Sheehan (2) have reported a milder esterification procedure in which the protected amino acid must be activated separately with carbonyl diimidazole and then reacted with the hydroxymethyl form of the polymer.