Solid phase peptide synthesis: Fluoride ion release of peptide from the resin
β Scribed by R. Ramage; C.A. Barron; S. Bielecki; D.W. Thomas
- Book ID
- 108383155
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 228 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
We report that solid-phase hydrothiolysis is an efficient method to convert resin-bound peptide thioesters to thioacids in aqueous buffer by using a total PEG-based resin. Also demonstrated is the use of the so-prepared peptide thioacids in chemoselective amide bond formation reactions.
## Abstract The dangerous liquid HF, which in addition causes many sideβreactions, has successfully been replaced by the easyβtoβhandle organic acid methanesulfonic acid for the cleavage of small peptides from the standard Merrifield resin.