✦ LIBER ✦

Replacement of hydrogen fluoride in solid phase peptide synthesis by methanesulfonic acid

✍ Scribed by J. W. van Nispen; J. P. Polderdijk; W. P. A. Janssen; H. M. Greven

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 172 KB
Volume: 100
Category: Article
ISSN: 0165-0513
DOI: 10.1002/recl.19811001112

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The dangerous liquid HF, which in addition causes many side‐reactions, has successfully been replaced by the easy‐to‐handle organic acid methanesulfonic acid for the cleavage of small peptides from the standard Merrifield resin.

📜 SIMILAR VOLUMES

Combination of silyl carbamate and amino

Combination of silyl carbamate and amino acid fluoride for solid-phase peptide synthesis

✍ Kimitoshi Sakamoto; Yoshiaki Nakahara; Yukishige Ito 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 133 KB

Diketopiperadine (DKP) formation is an often encountered side reaction in the synthesis of peptide having C-terminal proline ester. A novel strategy for the avoidance of this side reaction was developed, which utilizes Pfp ester of Tsoc-amino acid and Fmoc-amino acid fluoride as the second and the t

Synthesis of peptide nucleic acids (PNA)

Synthesis of peptide nucleic acids (PNA) by submonomer solid-phase synthesis

✍ Lutz S. Richter; Ronald N. Zuckermann 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 250 KB

Synthesis of decapeptide ofl-aspartic ac

Synthesis of decapeptide ofl-aspartic acid and benzyl-l-aspartic acid by solid phase peptide synthesis

✍ Bong K. Yoo; M. A. Jalil Miah; Eung-Seok Lee; Kun Han 📂 Article 📅 2005 🏛 Springer 🌐 English ⚖ 497 KB

Incorporation of Cα-methyl amino acids b

Incorporation of Cα-methyl amino acids by solid phase peptide synthesis in a peptide sequence

✍ Alié Brunissen; Mimoun Ayoub; Solange Lavielle 📂 Article 📅 1996 🏛 Elsevier Science 🌐 French ⚖ 264 KB

S)-ctMethyimethionine, (S)-ctMethylleucine, 2-aminoisobutyric acid and (S)-otMethylphenylalanine have been incorporated by solid phase peptide strategy in a peptide sequence. The coupling reactions of these Boc-ctMe amino acids and of the following residue in the sequence were readily achieved afte

Azido Acids in a Novel Method of Solid-P

Azido Acids in a Novel Method of Solid-Phase Peptide Synthesis.

✍ Morten Meldal*; Maria A Juliano; Anita M Jansson 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 667 KB

Azido acids were producedfrom et-branchedacids by a-brominationwith NBS followedby 8ub8titution withsodiumazide andthe productswereusedin a novelmethodof solid-phase synthesis. The azido acids were transformedinto the highly activated acid chloridesandused synthesisof extremelyhinderedpeptidescontai

Peptide synthesis : Part 10. Use of pent

Peptide synthesis : Part 10. Use of pentafluorophenyl esters of fluorenylmethoxycarbonylamino acids in solid phase peptide synthesis

✍ Eric Atherton; Linda R. Cameron; Robert C. Sheppard 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 850 KB