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Combination of silyl carbamate and amino acid fluoride for solid-phase peptide synthesis

✍ Scribed by Kimitoshi Sakamoto; Yoshiaki Nakahara; Yukishige Ito

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 133 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00050-3

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✦ Synopsis

Diketopiperadine (DKP) formation is an often encountered side reaction in the synthesis of peptide having C-terminal proline ester. A novel strategy for the avoidance of this side reaction was developed, which utilizes Pfp ester of Tsoc-amino acid and Fmoc-amino acid fluoride as the second and the third amino acid, respectively. This strategy was applied to the synthesis of 37-53 fragment of the b-chain of human chorionic gonadotropin (hCG).

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