Combination of silyl carbamate and amino
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Kimitoshi Sakamoto; Yoshiaki Nakahara; Yukishige Ito
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Article
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2002
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Elsevier Science
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French
⚖ 133 KB
Diketopiperadine (DKP) formation is an often encountered side reaction in the synthesis of peptide having C-terminal proline ester. A novel strategy for the avoidance of this side reaction was developed, which utilizes Pfp ester of Tsoc-amino acid and Fmoc-amino acid fluoride as the second and the t