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Azido Acids in a Novel Method of Solid-Phase Peptide Synthesis.

โœ Scribed by Morten Meldal*; Maria A Juliano; Anita M Jansson

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
667 KB
Volume
38
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Azido acids were producedfrom et-branchedacids by a-brominationwith NBS followedby 8ub8titution withsodiumazide andthe productswereusedin a novelmethodof solid-phase synthesis. The azido acids were transformedinto the highly activated acid chloridesandused synthesisof extremelyhinderedpeptidescontainingup to foursuccessive diphenylglycineor Aib residues.By reactionof the geneticallyencodedamino acids with TfNqand then SGCIZtheyweretransformedinto a-azido acid chloridesused in solid-phase peptidesynthesiswithoutracemization. @1997 ElsevierScienceLtd.

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