Solid-phase Synthesis of Chemotactic Peptides Using α-Azido Acids
✍ Scribed by Christian W. Tornøe; Henrik Sengeløv; Morten Meldal
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 107 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1075-2617
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A new simple solid-phase method has been developed for synthesizing Boc-protected peptide nucleic acid (PNA) monomers. An immobilized backbone 3 was built on Expansin ® resin using an ester disulphide handle: 2-hydroxypropyl-dithio-2%-isobutyric acid (HPDI). The base acetic acids of thymine 5, Z-cyt
## Abstract Merrifield solid phase peptide synthesis has been the principle research procedure used in the study of the chemistry and biological use of deamidation of asparaginyl and glutaminyl residues in peptides and proteins during the past 40 years. During the initial years of investigation, it