α-Azido acids for direct use in solid-phase peptide synthesis
✍ Scribed by Christian W. Tornøe; Peg Davis; Frank Porreca; Morten Meldal
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 136 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1075-2617
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📜 SIMILAR VOLUMES
Established methodology for the preparation of peptide thioesters requires the use of t-butoxycarbonyl chemistry owing to the lability of thioester linkers to the nucleophilic reagents used in Fmoc solid phase peptide synthesis. Both the greater ease of use and the broad applicability of the method
## Abstract Many naturally occurring peptide acids, e.g., somatostatins, conotoxins, and defensins, contain a cysteine residue at the C‐terminus. Furthermore, installation of C‐terminal cysteine onto epitopic peptide sequences as a preliminary to conjugating such structures to carrier proteins is a