Swellographic Study of Peptide Resin Swelling Behavior during Solid Phase Peptide Synthesis
โ Scribed by Igor L. Rodionov; Irina A. Peshenko; Ludmila K. Baidakova; Vadim T. Ivanov
- Book ID
- 106452122
- Publisher
- Springer Netherlands
- Year
- 2007
- Tongue
- English
- Weight
- 351 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1573-3149
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๐ SIMILAR VOLUMES
We report that solid-phase hydrothiolysis is an efficient method to convert resin-bound peptide thioesters to thioacids in aqueous buffer by using a total PEG-based resin. Also demonstrated is the use of the so-prepared peptide thioacids in chemoselective amide bond formation reactions.
Three short peptides were synthesized on Merrifield resin (PS-DVB) and on polystyrene crosslinked with 1,6-hexanediol diacrylate resin (PS-HDODA) to compare their efficiencies in solid-phase peptide synthesis (SPPS). A 2% crosslinked polymeric system having almost equal capacity was used in both cas