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Sildenafil therapy in patients with sickle cell disease and pulmonary hypertension

✍ Scribed by Roberto F. Machado; Sabrina Martyr; Gregory J. Kato; Robyn J. Barst; Anastasia Anthi; Michael R. Robinson; Lori Hunter; Wynona Coles; James Nichols; Christian Hunter; Vandana Sachdev; Oswaldo Castro; Mark T. Gladwin


Book ID
108673312
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
174 KB
Volume
130
Category
Article
ISSN
0007-1048

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In patients with sickle cell disease, anemia is a recognized risk factor for stroke, death, and the development of pulmonary hypertension. We have proposed that hemolytic anemia results in endothelial dysfunction and vascular instability and can ultimately lead to a proliferative vasculopathy leadin