A convergent synthesis of (&tothecin is described. Camptothecin (If, isolated by M C Wani and his coworkers1 from the bark of Camptotheta acuminta, has shown tremendous potential as an antitumor and antileukemic agent.' Off late Camptothecin and its anologs have emerged as the most promising comp
โฆ LIBER โฆ
Short synthesis of camptothecin
โ Scribed by Bradley, Joel C.; Buechi, George.
- Book ID
- 124061135
- Publisher
- American Chemical Society
- Year
- 1976
- Tongue
- English
- Weight
- 430 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
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A . F Wells. A<ru C'J I siuNogr. S c ~r A. 1986.42. 133. We are indebted to one of [7] G . M. Sheidrick. SHELX-76, Proxriiix /oi-C~.i..sro/ S i r i i m i t -c D ~, ~~~I -I I ~~I ~~I I ; ~J I ? . Condensation of phosphonate 4, Y = Z = H, with aldehyde 5 (vide infra) afforded enone 7, [ X I : ' = -56.
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