Regioselective synthesis of camptothecin

✍ Scribed by AV Rama Rao; J.S. Yadav; Muralikrishna Valluri

• Book ID: 104214475
• Publisher: Elsevier Science
• Year: 1994
• Tongue: French
• Weight: 246 KB
• Volume: 35
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)73254-0

✦ Synopsis

A convergent synthesis of (&amptothecin is described. Camptothecin (If, isolated by M C Wani and his coworkers1 from the bark of Camptotheta acuminta, has shown tremendous potential as an antitumor and antileukemic agent.' Off late Camptothecin and its anologs have emerged as the most promising compounds for the treatment of solid tumors.3 Recent findings have shown that camptothecin demonstrated exceptionai antiretroviral activity at dose levels well tolerated by ceils which prompted its development as an effective drug in the new direction of AIDS chemotherapy.4 Activity apart, the unusual structural features of the molecule are the a-hydroxy iactone and a pyridone ring fused to a five membered ring, which makes it a challenging synthetic target. Several