Urea-Mediated Regioselective Nitration of (20S)-Camptothecin.
โ Scribed by S. C. Puri; G. Handa; O. P. Suri; G. N. Qazi
- Book ID
- 101970911
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 15 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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๐ SIMILAR VOLUMES
Phenol (I) is nitrated regioselectively by fuming nitric acid inside the cages of faujasite zeolites. While nitration as hexane slurry in CsY and molecular sieve 5 ร leads to predominant formation of para-nitrophenol (III), a remarkable ortho-selectivity is observed in solid state nitration to yield
## Abstract The synthesis is given for three ring A tritiated camptothecin (CPT) analogs as biological probes in the study of the parent compounds which are of current widespread interest as potent anticancer agents. The strategy of catalytic tritolysis of aryl halide bonds was employed, and thus t
Montmorillonite impregnated with bismuth nitrate was found to be an excellent reagent for aromatic nitration in high yield.