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Short and Efficient Synthesis of Optically Active N-Tosyl Aziridines from 2-Amino Alcohols

✍ Scribed by Bieber, Lothar W.; de Araújo, Maria C. F.


Book ID
118191339
Publisher
Molecular Diversity Preservation International
Year
2002
Tongue
English
Weight
20 KB
Volume
7
Category
Article
ISSN
1420-3049

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## Abstract A series of optically active __N__‐protected α‐aminoketones were synthesized via the Grignard reaction of the Weinreb amides of the __N__‐__tert__‐butoxycarbonyl amino acids. Reduction of the α‐aminoketones by sodium borohydride resulted in the corresponding 1,2‐amino alcohols. © 2003 W