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Synthesis of optically active N-protected α-aminoketones and α-amino alcohols

✍ Scribed by Zheng Hong Zhou; Yi Long Tang; Kang Ying Li; Bing Liu; Chu Chi Tang

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 75 KB
Volume: 14
Category: Article
ISSN: 1042-7163
DOI: 10.1002/hc.10195

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✦ Synopsis

Abstract

A series of optically active N‐protected α‐aminoketones were synthesized via the Grignard reaction of the Weinreb amides of the N‐tert‐butoxycarbonyl amino acids. Reduction of the α‐aminoketones by sodium borohydride resulted in the corresponding 1,2‐amino alcohols. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:603–606, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10195

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