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An Efficient Method for Preparation of Optically Active N-Protected α-Amino Aldehydes from N-Protected α-Amino Alcohols

✍ Scribed by Souček, Milan; Urban, Ján


Book ID
111892451
Publisher
UOCHB
Year
1995
Tongue
English
Weight
38 KB
Volume
60
Category
Article
ISSN
0010-0765

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## Abstract A series of optically active __N__‐protected α‐aminoketones were synthesized via the Grignard reaction of the Weinreb amides of the __N__‐__tert__‐butoxycarbonyl amino acids. Reduction of the α‐aminoketones by sodium borohydride resulted in the corresponding 1,2‐amino alcohols. © 2003 W