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Selective Inhibitors of Dihydrofolate Reductase (Nobel Lecture)

✍ Scribed by Prof. George H. Hitchings Jr.

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
602 KB
Volume
28
Category
Article
ISSN
0044-8249

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πŸ“œ SIMILAR VOLUMES

Capillary electrophoresis separation of
Capillary electrophoresis separation of sulphonamides and dihydrofolate reductase inhibitors
✍ Maria C. Ricci; Reginald F. Cross πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 690 KB

## Abstract Twenty‐two sulphonamides and three dihydrofolate reductase inhibitors (DHFR) were included in this study. At pH 7.5, eighteen drugs were resolved in 22 min. Above pH 7.5 the DHFR are not resolved and the pH range of 7‐7.5 was found to be optimal. Around pH 7, where the degree of ionizat