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ChemInform Abstract: Novel Inhibitors of Trypanosoma cruzi Dihydrofolate Reductase.

✍ Scribed by Fabio Zuccotto; Marketa Zvelebil; Reto Brun; Shafinaz F. Chowdhury; Raffaella Di Lucrezia; Isabel Leal; Louis Maes; Luis M. Ruiz-Perez; Dolores Gonzalez Pacanowska; Ian H. Gilbert

Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
32
Category
Article
ISSN
0931-7597

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ChemInform Abstract: New Potent Inhibito
ChemInform Abstract: New Potent Inhibitors of Trypanothione Reductase from Trypanosoma cruzi in the 2-Aminodiphenylsulfide Series.
✍ S. GIRAULT; S. BAILLET; D. HORVATH; V. LUCAS; E. DAVIOUD-CHARVET; A. TARTAR; C. πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 28 KB πŸ‘ 1 views

New Potent Inhibitors of Trypanothione Reductase from Trypanosoma cruzi in the 2-Aminodiphenylsulfide Series. -A series of compounds such as (I)-(III) are prepared to investigate their TR inhibition. Derivative (Ib) is revealed to be the best inhibitor described so far.