ChemInform Abstract: The Structure-Based Design and Synthesis of Selective Inhibitors of Trypanosoma Cruzi Dihydrofolate Reductase.
โ Scribed by Fabio Zuccotto; Reto Brun; Dolores Gonzalez Pacanowska; Luis M. Ruiz Perez; Ian H. Gilbert
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 31 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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New Potent Inhibitors of Trypanothione Reductase from Trypanosoma cruzi in the 2-Aminodiphenylsulfide Series. -A series of compounds such as (I)-(III) are prepared to investigate their TR inhibition. Derivative (Ib) is revealed to be the best inhibitor described so far.