Role of hMLH1 and E-Cadherin Promoter Methylation in Gastric Cancer Progression
โ Scribed by Moghbeli, Meysam; Moaven, Omeed; Memar, Bahram; Raziei, Hamid Reza; Aarabi, Azadeh; Dadkhah, Ezzat; Forghanifard, Mohammad Mahdi; Manzari, Fatemeh; Abbaszadegan, Mohammad Reza
- Book ID
- 125377247
- Publisher
- Springer US
- Year
- 2013
- Tongue
- English
- Weight
- 243 KB
- Volume
- 45
- Category
- Article
- ISSN
- 1941-6628
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Microsatellite instability (MSI), which is recognized as an important mechanism in tumorigenesis, has been reported in familial gastric cancers (FGC). However, genetic defects responsible for this phenotype, that is, mutations in mismatchrepair genes such as hMLH1 and hMSH2, have not been detected i
To determine whether methylation of the hMLH1 promoter is related to increasing age and gastric carcinogenesis, we examined hMLH1 methylation and expression in 100 gastric cancers. hMLH1 methylation and aberrant protein expression were observed in 9 and 13 cancers, respectively. Normal and intestina